幼儿期发育迟缓与成年期心脏病风险因素的关系

幼年发育迟缓可能会对人体构成产生长期影响,导致与肥胖相关的共同体。我们测试了一个假设,即在幼年发育迟缓的个体在成年后期可能会有更高的心脏代谢风险。参加1982年佩洛塔斯(巴西)出生队列研究的1753名男子和1781名妇女对30岁时的人体测量、身体成分、血脂、葡萄糖、血压和其他心肌代谢特征进行了测量。根据世界卫生组织的成长标准,在两岁以下的年龄段,早期发育迟缓被定义为"高与年龄匹配"。采用线性回归模型对性别、母亲种族/族裔、出生时家庭收入和出生体重进行控制。当p-互动时,分析按性别分层。发育迟缓的个体较短。95%CI:-0。78 to -0.64), had lower BMI (β = -0.14 s.d.; 95%CI: -0.25 to -0.03), fat mass (β = -0.28 s.d.; 95%CI: -0.38 to -0.17), SAFT (β = -0.16 s.d.; 95%CI: -0.26 to -0.06), systolic (β = -0.12 s.d.; 95%CI: -0.21 to -0.02) and diastolic blood pressure (β = -0.11 s.d.; 95%CI: -0.22 to -0.01), and higher VFT/SAFT ratio (β = 0.15 s.d.; 95%CI: 0.06 to 0.24), in comparison with non-stunted individuals. In addition, early stunting was associated with lower fat free mass in both men (β = -0.39 s.d.; 95%CI: -0.47 to -0.31) and women (β = -0.37 s.d.; 95%CI: -0.46 to -0.29) after adjustment for potential confounders. Our results suggest that early stunting has implications on attained height, body composition and blood pressure.发育迟缓的个体积累较少的无脂物质和皮下脂肪的明显趋势可能使他们在以后的生活中更容易受到代谢风险的增加。